Polyphosphazene Microcapsules Fabricated through Covalent Assembly.

نویسندگان

  • Zhiqiang Feng
  • Guoqiang Fan
  • Hongxia Wang
  • Changyou Gao
  • Jiacong Shen
چکیده

Hollow polyphosphazene microcapsules have been fabricated by the covalent layer-by-layer assembly of polydichlorophosphazene (PDCP) and hexamethylenediamine (HDA) on aminosilanized silica particles, followed by core removal in a HF/NH(4) F solution. The hollow and intact microcapsules in both wet and dry states have been characterized by transmission electron microscopy and confocal laser scanning microscopy. The chemical structure of the microcapsules has been verified by FT-IR spectroscopy. The microcapsules could be hydrolytically degraded in a phosphate buffer at biological pH.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Direct Covalent Assembly to Fabricate Microcapsules with Ultrathin Walls and High Mechanical Strength

Microcapsules with ultrathin wall and high stability are of both scientific and technological importance. They can provide ideal models for investigations of permeability, elasticity and responsivity on a nanometer scale, and be used as microcarriers and micro-reactors in a confined space. Among the established techniques such as nozzle reactor process, emulsion/phase separation, sol-gel proces...

متن کامل

Self-assembly of polyphosphazene immunoadjuvant with poly(ethylene oxide) enables advanced nanoscale delivery modalities and regulated pH-dependent cellular membrane activity

Water-soluble polyphosphazene polyacids, such as poly[di(carboxylatophenoxy)phosphazene] (PCPP), have been of significant interest due to their unique immunoadjuvant and vaccine delivery properties. We report that PCPP can spontaneously self-assemble into intermolecular complexes with common formulation excipients - polyethers in aqueous solutions at neutral pH through the establishment of hydr...

متن کامل

Fabrication of diverse microcapsule arrays of high density and good stability.

Microcapsule arrays attract a lot of interest due to their potential applications in sensing technology. A strategy for fabricating diverse microcapsule arrays through covalent linking is reported here. The self-assembly of microcapsules was directed by using a poly(allylamine hydrochloride) (PAH)-patterned template, which was created via microcontact printing. The microcapsules with PAH as the...

متن کامل

Dendrimers in layer-by-layer assemblies: synthesis and applications.

We review the synthesis of dendrimer-containing layer-by-layer (LbL) assemblies and their applications, including biosensing, controlled drug release, and bio-imaging. Dendrimers can be built into LbL films and microcapsules by alternating deposition of dendrimers and counter polymers on the surface of flat substrates and colloidal microparticles through electrostatic bonding, hydrogen bonding,...

متن کامل

Covalent layer-by-layer assembly of hyperbranched polymers on alginate microcapsulesto impart stability and permselectivity.

The microencapsulation of cells has shown promise as a therapeutic vehicle for the treatment of a wide variety of diseases. While alginate microcapsules provide an ideal cell encapsulation material, polycations coatings are commonly employed to enhance stability and impart permselectivity. In this study, functionalized hyperbranched alginate and dendrimer polymers were used to generate discreet...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Macromolecular rapid communications

دوره 30 6  شماره 

صفحات  -

تاریخ انتشار 2009